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簡要描述：組織相容性抗原DQA1重組兔單克隆抗體免 疫 原；KLH conjugated synthetic peptide derived from human HLA-DQA1
產(chǎn)品型號：GOY-01K1399廠商性質(zhì)：科研更新時間：2023-10-24 00:00:00訪 問 量：150產(chǎn)品分類
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組織相容性抗原DQA1重組兔單克隆抗體
產(chǎn)品名稱 | 英文名稱 | 貨號 |
組織相容性抗原DQA1重組兔單克隆抗體 | HLA-DQA1 | GOY-01K1399 |
商品屬性：
英文名稱: HLA-DQA1
中文名:組織相容性抗原DQA1重組兔單克隆抗體
別 名；CD; CELIAC1; DC 1
alpha chain; DC alpha; DC-1 alpha chain; DC-alpha; DC1, included; DQ alpha 1
chain; DQ-A1; DQ-DRW9 alpha chain; DQA1_HUMAN; FLJ27088; FLJ27328;
Gluten-sensitive enteropathy (celiac disease); GSE; HLA class II
histocompatibility antigen; HLA class II histocompatibility antigen, DQ alpha 1
chain; HLA class II histocompatibility antigen, DQ(W3) alpha chain; HLA-DCA;
HLA-DQA; HLA-DQA1; HLA-DQA1 major histocompatibility complex, class II, DQ
alpha 1; HLADC histocompatibility type; Immune response antigens HIa, included;
leucocyte antigen DQA1; leukocyte antigen alpha chain; Major histocompatibility
complex, class II, DQ alpha 1; MGC149527; MHC class II antigen; MHC class II
DQA1; MHC class II HLA-D alpha glycoprotein; MHC class II HLA-DQ alpha 1; MHC
class II surface glycoprotein; MHC HLA-DQ alpha; OTTHUMP00000029141;
OTTHUMP00000176885; OTTHUMP00000178551; OTTHUMP00000178552; OTTHUMP00000233817.
研究領(lǐng)域；細胞生物 免疫學(xué) 轉(zhuǎn)運蛋白
抗體來源；Rabbit
克隆類型；Monoclonal
克 隆 號8C1
交叉反應(yīng)；Human,
Mouse, Rat,
產(chǎn)品應(yīng)用；WB=1:500-2000
IP=1:10-50 IHC-P=1:50-200 IHC-F=1:50-200 IF=1:50-200 （石蠟切片需做抗原修復(fù)）
not yet tested in
other applications.
optimal
dilutions/concentrations should be determined by the end user.
理論分子量；26kDa
細胞定位；細胞膜
性 狀；Liquid
濃 度；1mg/ml
免 疫 原；KLH
conjugated synthetic peptide derived from human HLA-DQA1
亞 型；IgG
純化方法；affinity
purified by Protein A
緩 沖 液；0.01M
TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件；Shipped at
4℃. Store at -20 °C for one
year. Avoid repeated freeze/thaw cycles.
注意事項；This
product as supplied is intended for research use only, not for use in human,
therapeutic or diagnostic applications.
產(chǎn)品介紹:
Binds peptides derived from antigens that access
the endocytic route of antigen presenting cells (APC) and presents them on
the cell surface for recognition by the CD4 T-cells. The peptide binding
cleft accomodates peptides of 10-30 residues. The peptides presented by MHC
class II molecules are generated mostly by degradation of proteins that
access the endocytic route, where they are processed by lysosomal proteases
and other hydrolases. Exogenous antigens that have been endocytosed by the
APC are thus readily available for presentation via MHC II molecules, and for
this reason this antigen presentation pathway is usually referred to as
exogenous. As membrane proteins on their way to degradation in lysosomes as
part of their normal turn-over are also contained in the endosomal/lysosomal
compartments, exogenous antigens must compete with those derived from
endogenous components. Autophagy is also a source of endogenous peptides,
autophagosomes constitutively fuse with MHC class II loading compartments. In
addition to APCs, other cells of the gastrointestinal tract, such as
epithelial cells, express MHC class II molecules and CD74 and act as APCs,
which is an unusual trait of the GI tract. To produce a MHC class II molecule
that presents an antigen, three MHC class II molecules (heterodimers of an
alpha and a beta chain) associate with a CD74 trimer in the ER to form an
heterononamer. Soon after the entry of this complex into the endosomal/lysosomal
system where antigen processing occurs, CD74 undergoes a sequential
degradation by various proteases, including CTSS and CTSL, leaving a small
fragment termed CLIP (class-II-associated invariant chain peptide). The
removal of CLIP is facilitated by HLA-DM via direct binding to the
alpha-beta-CLIP complex so that CLIP is released. HLA-DM stabilizes MHC class
II molecules until primary high affinity antigenic peptides are bound. The
MHC II molecule bound to a peptide is then transported to the cell membrane
surface. In B cells, the interaction between HLA-DM and MHC class II
molecules is regulated by HLA-DO. Primary dendritic cells (DCs) also to
express HLA-DO. Lysosomal miroenvironment has been implicated in the
regulation of antigen loading into MHC II molecules, increased acidification
produces increased proteolysis and efficient peptide loading. |
多克隆抗體制備：
我公司合成抗原，保證陽性血清和抗體ELISA效價達到1：32000，由蛋白抗原制備的多抗，保證WB檢測結(jié)果是陽性。技術(shù)服務(wù)實行分步報價，按節(jié)點收費，為客戶節(jié)約成本。
鼠單克隆抗體制備:
客戶可根據(jù)項目實際需求情況靈活選擇進行，我公司將為您的項目提供專業(yè)的建議。在制備過程中，與客戶互動驗證，確保最終制備的抗體ELISA陽性血清檢測達到合同要求的同時，也能滿足客戶抗體最終應(yīng)用驗證需求。技術(shù)服務(wù)實行分步報價，按節(jié)點收費，為客戶節(jié)約成本。
重組抗體表達服務(wù):
重組抗體技術(shù)使制備人源化抗體和人源抗體成為可能，而這是其他常規(guī)的多克隆或單克隆抗體制備方法無法做到的。我公司已搭建好的抗體測序、重組抗體表達等先進平臺，能為客戶提供各種類型的重組抗體表達服務(wù)，包含鼠源單克隆抗體構(gòu)建及表達、更換恒定區(qū)亞型的嵌合抗體表達，抗體人源化改造及表達等服務(wù)。
單項免疫學(xué)及檢測服務(wù):
我公司也為客戶提供單項免疫學(xué)和檢測服務(wù)，如動物免疫、動物飼養(yǎng)、抗體修飾服務(wù)（如FITC，HRP等的標(biāo)記）、以及ELISA，WB，IHC，DB等檢測服務(wù)。
抗體定制服務(wù):
已注冊商標(biāo)，主要用于抗體藥物發(fā)現(xiàn)和開發(fā)，是我公司針對有特定應(yīng)用要求和各種模型測試的客戶量身定制的專業(yè)服務(wù)，主要面向工業(yè)客戶。
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