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簡要描述：羥基類固醇(17β)脫氫酶4/17β-HSD4抗體注意事項；This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
產(chǎn)品型號：GOY-01K1680廠商性質(zhì)：科研更新時間：2023-10-24 00:00:00訪 問 量：139產(chǎn)品分類
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羥基類固醇(17β)脫氫酶4/17β-HSD4抗體
產(chǎn)品名稱 | 英文名稱 | 貨號 |
羥基類固醇(17β)脫氫酶4/17β-HSD4抗體 | HSD17B4 | GOY-01K1680 |
商品屬性：
英文名稱: HSD17B4
中文名:羥基類固醇(17β)脫氫酶4/17β-HSD4抗體
別 名；hydroxysteroid
(17-beta) dehydrogenase 4; 12-alpha-trihydroxy-5-beta-cholest-24-enoyl-CoA
hydratase; 17 beta HSD 4; 17 beta HSD IV; 17 beta hydroxysteroid dehydrogenase
4; 17-beta-HSD 4; 17-beta-hydroxysteroid dehydrogenase 4; 17beta estradiol
dehydrogenase type IV; 3 alpha 7 alpha12 alpha trihydroxy 5 beta cholest 24
enoyl CoA hydratase antibody 3-alpha; 7-alpha; Beta hydroxyacyl dehydrogenase;
Beta keto reductase; D 3 hydroxyacyl CoA dehydratase; D bifunctional protein; D
bifunctional protein peroxisomal; D-bifunctional protein; DBP; DHB4_HUMAN; EDH17B4;
Enoyl-CoA hydratase 2; Hsd17b4; MFE 2; MFE-2; MPF-2; Multifunctional protein 2;
Peroxisomal multifunctional enzyme type 2; Peroxisomal multifunctional protein
2; SDR8C1; Short chain dehydrogenase/reductase family 8C member 1; 17β-HSD4.
研究領(lǐng)域；腫瘤 心血管 細胞生物 神經(jīng)生物學(xué) 信號轉(zhuǎn)導(dǎo) 線粒體
抗體來源；Rabbit
克隆類型；Polyclonal
交叉反應(yīng)；(predicted:
Human, Mouse, Rat, Chicken, Pig, Cow, Horse, Sheep, Guinea Pig, )
產(chǎn)品應(yīng)用；WB=1:500-2000
ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)）
not yet tested in
other applications.
optimal
dilutions/concentrations should be determined by the end user.
理論分子量；47/80kDa
細胞定位；細胞漿 線粒體
性 狀；Liquid
濃 度；1mg/ml
免 疫 原；KLH
conjugated synthetic peptide derived from human HSD17B4 Enoyl-CoA hydratase 2:
521-620/736
亞 型；IgG
純化方法；affinity
purified by Protein A
緩 沖 液；0.01M
TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
注意事項；This
product as supplied is intended for research use only, not for use in human,
therapeutic or diagnostic applications.
產(chǎn)品介紹:
17Beta-HSD4 (17Beta-hydroxysteroid dehydrogenase
type 4) is also known as peroxisomal multifunctional enzyme/protein 2
(MFE-2/MFP-2), D-bifunctional enzyme or 17-Beta Estradiol dehydrogenase type
IV. It belongs to the 17Beta-HSD family of proteins that regulate the
availability of steroids within various tissues throughout the body.
17Beta-HSD4 inactivates Estradiol through its oxidative activity but it is
primarily involved in peroxisomal fatty acid and cholesterol Beta-oxidation.
It has a multi-domain structure: the dehydrogenase domain is fused to a
hydratase and a lipid transfer domain. 17Beta-HSD4 is a target protein of
chromeceptin and it is essential for the downstream activation of Stat6.
17Beta-HSD4-deficient patients exhibit Zellweger-like syndrome and die within
the first year of life. They display neuronal migration defects, facial
dysmorphisms, severe hypotonia and convulsions in the neonatal period. |
多克隆抗體制備：
我公司合成抗原，保證陽性血清和抗體ELISA效價達到1：32000，由蛋白抗原制備的多抗，保證WB檢測結(jié)果是陽性。技術(shù)服務(wù)實行分步報價，按節(jié)點收費，為客戶節(jié)約成本。
鼠單克隆抗體制備:
客戶可根據(jù)項目實際需求情況靈活選擇進行，我公司將為您的項目提供專業(yè)的建議。在制備過程中，與客戶互動驗證，確保最終制備的抗體ELISA陽性血清檢測達到合同要求的同時，也能滿足客戶抗體最終應(yīng)用驗證需求。技術(shù)服務(wù)實行分步報價，按節(jié)點收費，為客戶節(jié)約成本。
重組抗體表達服務(wù):
重組抗體技術(shù)使制備人源化抗體和人源抗體成為可能，而這是其他常規(guī)的多克隆或單克隆抗體制備方法無法做到的。我公司已搭建好的抗體測序、重組抗體表達等先進平臺，能為客戶提供各種類型的重組抗體表達服務(wù)，包含鼠源單克隆抗體構(gòu)建及表達、更換恒定區(qū)亞型的嵌合抗體表達，抗體人源化改造及表達等服務(wù)。
單項免疫學(xué)及檢測服務(wù):
我公司也為客戶提供單項免疫學(xué)和檢測服務(wù)，如動物免疫、動物飼養(yǎng)、抗體修飾服務(wù)（如FITC，HRP等的標記）、以及ELISA，WB，IHC，DB等檢測服務(wù)。
抗體定制服務(wù):
已注冊商標，主要用于抗體藥物發(fā)現(xiàn)和開發(fā)，是我公司針對有特定應(yīng)用要求和各種模型測試的客戶量身定制的專業(yè)服務(wù)，主要面向工業(yè)客戶。
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