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簡(jiǎn)要描述：核蛋白相互作用蛋白2抗體免 疫 原；KLH conjugated synthetic peptide derived from human KPNA2: 1-100/529
產(chǎn)品型號(hào)：GOY-01K0278廠商性質(zhì)：科研更新時(shí)間：2023-10-24 00:00:00訪 問 量：142產(chǎn)品分類
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核蛋白相互作用蛋白2抗體
產(chǎn)品名稱 | 英文名稱 | 貨號(hào) |
核蛋白相互作用蛋白2抗體 | KPNA2 | GOY-01K0278 |
商品屬性：
英文名稱: KPNA2
中文名:核蛋白相互作用蛋白2抗體
別 名；IMA2_HUMAN;
Importin alpha 1; Importin alpha 2; Importin alpha 2 subunit; Importin alpha
P1; Importin subunit alpha-2; IPO A1; IPOA 1; IPOA1; Karyopherin alpha 2;
Karyopherin alpha 2 RAG cohort 1; Karyopherin alpha 2 subunit; Karyopherin
subunit alpha-2; KPNA 2; KPNA2; KPNA2 protein; Pendulin; QIP 2; QIP2; RAG
cohort 1; RAG cohort protein 1; RCH 1; RCH1; SRP 1; SRP1 alpha; SRP1;
SRP1-alpha; SRP1alpha.
研究領(lǐng)域；細(xì)胞生物 染色質(zhì)和核信號(hào) 信號(hào)轉(zhuǎn)導(dǎo)
抗體來源；Rabbit
克隆類型；Polyclonal
交叉反應(yīng)；(predicted:
Human, Mouse, Rat, Pig, Cow, Horse, Rabbit, )
產(chǎn)品應(yīng)用；WB=1:500-2000
ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)）
not yet tested in
other applications.
optimal
dilutions/concentrations should be determined by the end user.
理論分子量；58kDa
細(xì)胞定位；細(xì)胞核 細(xì)胞漿
性 狀；Liquid
濃 度；1mg/ml
免 疫 原；KLH
conjugated synthetic peptide derived from human KPNA2: 1-100/529
亞 型；IgG
純化方法；affinity
purified by Protein A
緩 沖 液；0.01M
TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
注意事項(xiàng)；This
product as supplied is intended for research use only, not for use in human,
therapeutic or diagnostic applications.
產(chǎn)品介紹:
The import of proteins into the nucleus is a
process that involves at least 2 steps. The first is an energy-independent
docking of the protein to the nuclear envelope and the second is an
energy-dependent translocation through the nuclear pore complex. Imported
proteins require a nuclear localization sequence (NLS) which generally
consists of a short region of basic amino acids or 2 such regions spaced
about 10 amino acids apart. Proteins involved in the first step of nuclear
import have been identified in different systems. These include the Xenopus
protein importin and its yeast homolog, SRP1 (a suppressor of certain temperature-sensitive
mutations of RNA polymerase I in Saccharomyces cerevisiae), which bind to the
NLS. KPNA2 protein interacts with the NLSs of DNA helicase Q1 and SV40 T
antigen and may be involved in the nuclear transport of proteins. KPNA2 also
may play a role in V(D)J recombination [provided by RefSeq, Jul 2008] Functions in nuclear protein import as an adapter
protein for nuclear receptor KPNB1. Binds specifically and directly to
substrates containing either a simple or bipartite NLS motif. Docking of the
importin/substrate complex to the nuclear pore complex (NPC) is mediated by
KPNB1 through binding to nucleoporin FxFG repeats and the complex is
subsequently translocated through the pore by an energy requiring,
Ran-dependent mechanism. At the nucleoplasmic side of the NPC, Ran binds to
importin-beta and the three components separate and importin-alpha and -beta
are re-exported from the nucleus to the cytoplasm where GTP hydrolysis
releases Ran from importin. The directionality of nuclear import is thought to
be conferred by an asymmetric distribution of the GTP- and GDP-bound forms of
Ran between the cytoplasm and nucleus. |
多克隆抗體制備：
我公司合成抗原，保證陽性血清和抗體ELISA效價(jià)達(dá)到1：32000，由蛋白抗原制備的多抗，保證WB檢測(cè)結(jié)果是陽性。技術(shù)服務(wù)實(shí)行分步報(bào)價(jià)，按節(jié)點(diǎn)收費(fèi)，為客戶節(jié)約成本。
鼠單克隆抗體制備:
客戶可根據(jù)項(xiàng)目實(shí)際需求情況靈活選擇進(jìn)行，我公司將為您的項(xiàng)目提供專業(yè)的建議。在制備過程中，與客戶互動(dòng)驗(yàn)證，確保最終制備的抗體ELISA陽性血清檢測(cè)達(dá)到合同要求的同時(shí)，也能滿足客戶抗體最終應(yīng)用驗(yàn)證需求。技術(shù)服務(wù)實(shí)行分步報(bào)價(jià)，按節(jié)點(diǎn)收費(fèi)，為客戶節(jié)約成本。
重組抗體表達(dá)服務(wù):
重組抗體技術(shù)使制備人源化抗體和人源抗體成為可能，而這是其他常規(guī)的多克隆或單克隆抗體制備方法無法做到的。我公司已搭建好的抗體測(cè)序、重組抗體表達(dá)等先進(jìn)平臺(tái)，能為客戶提供各種類型的重組抗體表達(dá)服務(wù)，包含鼠源單克隆抗體構(gòu)建及表達(dá)、更換恒定區(qū)亞型的嵌合抗體表達(dá)，抗體人源化改造及表達(dá)等服務(wù)。
單項(xiàng)免疫學(xué)及檢測(cè)服務(wù):
我公司也為客戶提供單項(xiàng)免疫學(xué)和檢測(cè)服務(wù)，如動(dòng)物免疫、動(dòng)物飼養(yǎng)、抗體修飾服務(wù)（如FITC，HRP等的標(biāo)記）、以及ELISA，WB，IHC，DB等檢測(cè)服務(wù)。
抗體定制服務(wù):
已注冊(cè)商標(biāo)，主要用于抗體藥物發(fā)現(xiàn)和開發(fā)，是我公司針對(duì)有特定應(yīng)用要求和各種模型測(cè)試的客戶量身定制的專業(yè)服務(wù)，主要面向工業(yè)客戶。
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