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簡(jiǎn)要描述：KPNA5蛋白抗體免 疫 原；KLH conjugated synthetic peptide derived from human KPNA5: 1-100/538
產(chǎn)品型號(hào)：GOY-01K5134廠商性質(zhì)：科研更新時(shí)間：2023-10-24 00:00:00訪 問 量：148產(chǎn)品分類
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KPNA5蛋白抗體
產(chǎn)品名稱 | 英文名稱 | 貨號(hào) |
KPNA5蛋白抗體 | KPNA5 | GOY-01K5134 |
商品屬性：
英文名稱: KPNA5
中文名:KPNA5蛋白抗體
別 名；IMA5_HUMAN;
Importin alpha 6; Importin subunit alpha 6; Importin subunit alpha-6; IPOA 6;
IPOA6; Karyopherin alpha 5; Karyopherin alpha 5 importin alpha 6; Karyopherin
subunit alpha 5; Karyopherin subunit alpha-5; KPNA 5; KPNA5; SRP 6; SRP6.
研究領(lǐng)域；細(xì)胞生物 信號(hào)轉(zhuǎn)導(dǎo)
抗體來源；Rabbit
克隆類型；Polyclonal
交叉反應(yīng)；(predicted:
Human, Mouse, Rat, Chicken, Pig, Cow, Horse, Rabbit, Sheep, )
產(chǎn)品應(yīng)用；IHC-P=1:100-500
IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)）
not yet tested in other
applications.
optimal
dilutions/concentrations should be determined by the end user.
理論分子量；52kDa
細(xì)胞定位；細(xì)胞漿
性 狀；Liquid
濃 度；1mg/ml
免 疫 原；KLH
conjugated synthetic peptide derived from human KPNA5: 1-100/538
亞 型；IgG
純化方法；affinity
purified by Protein A
緩 沖 液；0.01M
TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
注意事項(xiàng)；This
product as supplied is intended for research use only, not for use in human,
therapeutic or diagnostic applications.
產(chǎn)品介紹:
The transport of molecules between the nucleus and
the cytoplasm in eukaryotic cells is mediated by the nuclear pore complex
(NPC) which consists of 60-100 proteins and is probably 120 million daltons
in molecular size. Small molecules (up to 70 kD) can pass through the nuclear
pore by nonselective diffusion; larger molecules are transported by an active
process. Most nuclear proteins contain short basic amino acid sequences known
as nuclear localization signals (NLSs). KPNA5 protein belongs to the importin
alpha protein family and is thought to be involved in NLS-dependent protein
import into the nucleus. [provided by RefSeq, Jul 2008] Functions in nuclear protein import as an adapter
protein for nuclear receptor KPNB1. Binds specifically and directly to
substrates containing either a simple or bipartite NLS motif. Docking of the
importin/substrate complex to the nuclear pore complex (NPC) is mediated by
KPNB1 through binding to nucleoporin FxFG repeats and the complex is
subsequently translocated through the pore by an energy requiring, Ran-dependent
mechanism. At the nucleoplasmic side of the NPC, Ran binds to importin-beta
and the three components separate and importin-alpha and -beta are
re-exported from the nucleus to the cytoplasm where GTP hydrolysis releases
Ran from importin. The directionality of nuclear import is thought to be
conferred by an asymmetric distribution of the GTP- and GDP-bound forms of
Ran between the cytoplasm and nucleus. Mediates nuclear import of STAT1
homodimers and STAT1/STAT2 heterodimers by recognizing non-classical NLSs of
STAT1 and STAT2 through ARM repeats 8-9. Recognizes influenza A virus
nucleoprotein through ARM repeat 7-9 In vitro, mediates the nuclear import of
human cytomegalovirus UL84 by recognizing a non-classical NLS. |
多克隆抗體制備：
我公司合成抗原，保證陽性血清和抗體ELISA效價(jià)達(dá)到1：32000，由蛋白抗原制備的多抗，保證WB檢測(cè)結(jié)果是陽性。技術(shù)服務(wù)實(shí)行分步報(bào)價(jià)，按節(jié)點(diǎn)收費(fèi)，為客戶節(jié)約成本。
鼠單克隆抗體制備:
客戶可根據(jù)項(xiàng)目實(shí)際需求情況靈活選擇進(jìn)行，我公司將為您的項(xiàng)目提供專業(yè)的建議。在制備過程中，與客戶互動(dòng)驗(yàn)證，確保最終制備的抗體ELISA陽性血清檢測(cè)達(dá)到合同要求的同時(shí)，也能滿足客戶抗體最終應(yīng)用驗(yàn)證需求。技術(shù)服務(wù)實(shí)行分步報(bào)價(jià)，按節(jié)點(diǎn)收費(fèi)，為客戶節(jié)約成本。
重組抗體表達(dá)服務(wù):
重組抗體技術(shù)使制備人源化抗體和人源抗體成為可能，而這是其他常規(guī)的多克隆或單克隆抗體制備方法無法做到的。我公司已搭建好的抗體測(cè)序、重組抗體表達(dá)等先進(jìn)平臺(tái)，能為客戶提供各種類型的重組抗體表達(dá)服務(wù)，包含鼠源單克隆抗體構(gòu)建及表達(dá)、更換恒定區(qū)亞型的嵌合抗體表達(dá)，抗體人源化改造及表達(dá)等服務(wù)。
單項(xiàng)免疫學(xué)及檢測(cè)服務(wù):
我公司也為客戶提供單項(xiàng)免疫學(xué)和檢測(cè)服務(wù)，如動(dòng)物免疫、動(dòng)物飼養(yǎng)、抗體修飾服務(wù)（如FITC，HRP等的標(biāo)記）、以及ELISA，WB，IHC，DB等檢測(cè)服務(wù)。
抗體定制服務(wù):
已注冊(cè)商標(biāo)，主要用于抗體藥物發(fā)現(xiàn)和開發(fā)，是我公司針對(duì)有特定應(yīng)用要求和各種模型測(cè)試的客戶量身定制的專業(yè)服務(wù)，主要面向工業(yè)客戶。
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