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簡(jiǎn)要描述：LIN7B蛋白抗體免 疫 原；KLH conjugated synthetic peptide derived from human LIN7B: 1-100/207
產(chǎn)品型號(hào)：GOY-01K5593廠商性質(zhì)：科研更新時(shí)間：2023-10-24 00:00:00訪(fǎng) 問(wèn) 量：147產(chǎn)品分類(lèi)
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LIN7B蛋白抗體
產(chǎn)品名稱(chēng) | 英文名稱(chēng) | 貨號(hào) |
LIN7B蛋白抗體 | LIN7B | GOY-01K5593 |
商品屬性：
英文名稱(chēng): LIN7B
中文名:LIN7B蛋白抗體
別 名；hVeli2; hLin7B;
hVeli2; Lin 7 homolog B C elegans; LIN 7B; Lin 7b protein likely ortholog of
mouse LIN 7B mammalian LIN 7 protein 2; Lin-7B; LIN7B; LIN7B_HUMAN; MALS 2; MALS-2;
MALS2; Mammalian lin seven protein 2; Mammalian lin-seven protein 2; Protein
lin 7 homolog B; Protein lin-7 homolog B; VELI 2; Veli-2; VELI2; Vertebrate lin
7 homolog 2; Vertebrate lin-7 homolog 2.
研究領(lǐng)域；細(xì)胞生物 免疫學(xué) 神經(jīng)生物學(xué) 信號(hào)轉(zhuǎn)導(dǎo) 細(xì)胞粘附分子
抗體來(lái)源；Rabbit
克隆類(lèi)型；Polyclonal
交叉反應(yīng)；(predicted:
Human, Mouse, Rat, Pig, Horse, )
產(chǎn)品應(yīng)用；ELISA=1:5000-10000
IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)）
not yet tested in
other applications.
optimal
dilutions/concentrations should be determined by the end user.
理論分子量；23kDa
細(xì)胞定位；細(xì)胞膜
性 狀；Liquid
濃 度；1mg/ml
免 疫 原；KLH
conjugated synthetic peptide derived from human LIN7B: 1-100/207
亞 型；IgG
純化方法；affinity
purified by Protein A
緩 沖 液；0.01M
TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
注意事項(xiàng)；This
product as supplied is intended for research use only, not for use in human,
therapeutic or diagnostic applications.
產(chǎn)品介紹:
Velis are a family of small synaptic proteins that
interact with other proteins at the post-synaptic density (PSD) of neuronal
synapses. Velis contain the PDZ motif involved in recruiting cell adhesion
molecules, receptors, and channels. Veli1 (also designated Lin-7-B and
MALS-1), Veli2 (also designated Lin-7A and MALS-2), and Veli3 (also
designated Lin-7C and MALS-3) are mammalian homologs of C. elegans LIN-7.
Veli proteins are ubiquitously expressed with high expression in brain,
liver, and testis. Velis are localized at the synaptic junctions in neurons.
Velis bind to CASK, a neurexin-binding protein highly concentrated in synapses,
and Mint1, a binding partner with a vesicle trafficking protein. Plays a role in establishing and maintaining the
asymmetric distribution of channels and receptors at the plasma membrane of
polarized cells. Forms membrane-associated multiprotein complexes that may
regulate delivery and recycling of proteins to the correct membrane domains.
The tripartite complex composed of LIN7 (LIN7A, LIN7B or LIN7C), CASK and
APBA1 may have the potential to couple synaptic vesicle exocytosis to cell
adhesion in brain. Ensures the proper localization of GRIN2B (subunit 2B of
the NMDA receptor) to neuronal postsynaptic density and may function in
localizing synaptic vesicles at synapses where it is recruited by
beta-catenin and cadherin. Required to localize Kir2 channels, GABA
transporter (SLC6A12) and EGFR/ERBB1, ERBB2, ERBB3 and ERBB4 to the
basolateral membrane of epithelial cells. May increase the amplitude of ACCN3
acid-evoked currents by stabilizing the channel at the cell surface. |
多克隆抗體制備：
我公司合成抗原，保證陽(yáng)性血清和抗體ELISA效價(jià)達(dá)到1：32000，由蛋白抗原制備的多抗，保證WB檢測(cè)結(jié)果是陽(yáng)性。技術(shù)服務(wù)實(shí)行分步報(bào)價(jià)，按節(jié)點(diǎn)收費(fèi)，為客戶(hù)節(jié)約成本。
鼠單克隆抗體制備:
客戶(hù)可根據(jù)項(xiàng)目實(shí)際需求情況靈活選擇進(jìn)行，我公司將為您的項(xiàng)目提供專(zhuān)業(yè)的建議。在制備過(guò)程中，與客戶(hù)互動(dòng)驗(yàn)證，確保最終制備的抗體ELISA陽(yáng)性血清檢測(cè)達(dá)到合同要求的同時(shí)，也能滿(mǎn)足客戶(hù)抗體最終應(yīng)用驗(yàn)證需求。技術(shù)服務(wù)實(shí)行分步報(bào)價(jià)，按節(jié)點(diǎn)收費(fèi)，為客戶(hù)節(jié)約成本。
重組抗體表達(dá)服務(wù):
重組抗體技術(shù)使制備人源化抗體和人源抗體成為可能，而這是其他常規(guī)的多克隆或單克隆抗體制備方法無(wú)法做到的。我公司已搭建好的抗體測(cè)序、重組抗體表達(dá)等先進(jìn)平臺(tái)，能為客戶(hù)提供各種類(lèi)型的重組抗體表達(dá)服務(wù)，包含鼠源單克隆抗體構(gòu)建及表達(dá)、更換恒定區(qū)亞型的嵌合抗體表達(dá)，抗體人源化改造及表達(dá)等服務(wù)。
單項(xiàng)免疫學(xué)及檢測(cè)服務(wù):
我公司也為客戶(hù)提供單項(xiàng)免疫學(xué)和檢測(cè)服務(wù)，如動(dòng)物免疫、動(dòng)物飼養(yǎng)、抗體修飾服務(wù)（如FITC，HRP等的標(biāo)記）、以及ELISA，WB，IHC，DB等檢測(cè)服務(wù)。
抗體定制服務(wù):
已注冊(cè)商標(biāo)，主要用于抗體藥物發(fā)現(xiàn)和開(kāi)發(fā)，是我公司針對(duì)有特定應(yīng)用要求和各種模型測(cè)試的客戶(hù)量身定制的專(zhuān)業(yè)服務(wù)，主要面向工業(yè)客戶(hù)。
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