簡要描述:內(nèi)質(zhì)網(wǎng)α-甘露糖苷酶1抗體免 疫 原;KLH conjugated synthetic peptide derived from human MAN1B1: 211-320/699
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內(nèi)質(zhì)網(wǎng)α-甘露糖苷酶1抗體
產(chǎn)品名稱 | 英文名稱 | 貨號 |
內(nèi)質(zhì)網(wǎng)α-甘露糖苷酶1抗體 | MAN1B1 | GOY-01K5704 |
商品屬性:
英文名稱: MAN1B1
中文名:內(nèi)質(zhì)網(wǎng)α-甘露糖苷酶1抗體
別 名;Alpha 1 2
mannosidase; Endoplasmic reticulum alpha mannosidase 1; Endoplasmic reticulum
mannosyl oligosaccharide 1 2 alpha mannosidase 1; Endoplasmic reticulum
mannosyl oligosaccharide 1 2 alpha mannosidase; ER alpha 1 2 mannosidase;
Man9GlcNAc2 specific processing alpha mannosidase; MANA ER; Mannosidase alpha
class 1B member 1.
研究領(lǐng)域;細(xì)胞生物 免疫學(xué)
抗體來源;Rabbit
克隆類型;Polyclonal
交叉反應(yīng);(predicted:
Human, Mouse, Rat, Pig, Horse, )
產(chǎn)品應(yīng)用;ELISA=1:5000-10000
IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 (石蠟切片需做抗原修復(fù))
not yet tested in
other applications.
optimal
dilutions/concentrations should be determined by the end user.
理論分子量;80kDa
細(xì)胞定位;細(xì)胞漿 細(xì)胞膜
性 狀;Liquid
濃 度;1mg/ml
免 疫 原;KLH
conjugated synthetic peptide derived from human MAN1B1: 211-320/699
亞 型;IgG
純化方法;affinity
purified by Protein A
緩 沖 液;0.01M
TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
注意事項;This
product as supplied is intended for research use only, not for use in human,
therapeutic or diagnostic applications.
產(chǎn)品介紹:
This gene encodes an enzyme belonging to the
glycosyl hydrolase 47 family. This enzyme functions in N-glycan biosynthesis,
and is a class I alpha-1,2-mannosidase that specifically converts Man9GlcNAc
to Man8GlcNAc isomer B. It is required for N-glycan trimming to Man5-6GlcNAc2
in the endoplasmic-reticulum-associated degradation pathway. Mutations in
this gene cause autosomal-recessive intellectual disability. Alternative
splicing results in multiple transcript variants. A related pseudogene has
been identified on chromosome 11. [provided by RefSeq, Dec 2011] Involved in glycoprotein quality control targeting
of misfolded glycoproteins for degradation. It primarily trims a single
alpha-1,2-linked mannose residue from Man9GlcNAc2 to produce Man8GlcNAc2, but
at high enzyme concentrations, as found in the ER quality control compartment
(ERQC), it further trims the carbohydrates to Man5-6GlcNAc2. |
多克隆抗體制備:
我公司合成抗原,保證陽性血清和抗體ELISA效價達(dá)到1:32000,由蛋白抗原制備的多抗,保證WB檢測結(jié)果是陽性。技術(shù)服務(wù)實行分步報價,按節(jié)點收費,為客戶節(jié)約成本。
鼠單克隆抗體制備:
客戶可根據(jù)項目實際需求情況靈活選擇進(jìn)行,我公司將為您的項目提供專業(yè)的建議。在制備過程中,與客戶互動驗證,確保最終制備的抗體ELISA陽性血清檢測達(dá)到合同要求的同時,也能滿足客戶抗體最終應(yīng)用驗證需求。技術(shù)服務(wù)實行分步報價,按節(jié)點收費,為客戶節(jié)約成本。
重組抗體表達(dá)服務(wù):
重組抗體技術(shù)使制備人源化抗體和人源抗體成為可能,而這是其他常規(guī)的多克隆或單克隆抗體制備方法無法做到的。我公司已搭建好的抗體測序、重組抗體表達(dá)等先進(jìn)平臺,能為客戶提供各種類型的重組抗體表達(dá)服務(wù),包含鼠源單克隆抗體構(gòu)建及表達(dá)、更換恒定區(qū)亞型的嵌合抗體表達(dá),抗體人源化改造及表達(dá)等服務(wù)。
單項免疫學(xué)及檢測服務(wù):
我公司也為客戶提供單項免疫學(xué)和檢測服務(wù),如動物免疫、動物飼養(yǎng)、抗體修飾服務(wù)(如FITC,HRP等的標(biāo)記)、以及ELISA,WB,IHC,DB等檢測服務(wù)。
抗體定制服務(wù):
已注冊商標(biāo),主要用于抗體藥物發(fā)現(xiàn)和開發(fā),是我公司針對有特定應(yīng)用要求和各種模型測試的客戶量身定制的專業(yè)服務(wù),主要面向工業(yè)客戶。
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