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簡要描述：E3連接酶MMS21蛋白抗體免 疫 原；KLH conjugated synthetic peptide derived from human MMS21/NSE2: 21-120/247
產(chǎn)品型號：GOY-01K4303廠商性質(zhì)：科研更新時(shí)間：2023-10-24 00:00:00訪 問 量：154產(chǎn)品分類
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E3連接酶MMS21蛋白抗體
產(chǎn)品名稱 | 英文名稱 | 貨號 |
E3連接酶MMS21蛋白抗體 | NSE2/MMS21 | GOY-01K4303 |
商品屬性：
英文名稱: NSE2/MMS21
中文名:E3連接酶MMS21蛋白抗體
別 名；C8orf36; E3
SUMO-protein ligase NSE2; hMMS21; hNSE2; methyl methanesulfonate sensitivity
gene 21; MMS21; MMS21 homolog; non-SMC element 2; Non-SMC element 2 homolog;
Non-structural maintenance of chromosomes element 2 homolog; NSE2_HUMAN;
NSMCE2.
研究領(lǐng)域；細(xì)胞生物 細(xì)胞凋亡 表觀遺傳學(xué) 泛素
抗體來源；Rabbit
克隆類型；Polyclonal
交叉反應(yīng)；(predicted:
Human, Mouse, Rat, Dog, Cow, Horse, Rabbit, Sheep, )
產(chǎn)品應(yīng)用；WB=1:500-2000
ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)）
not yet tested in
other applications.
optimal
dilutions/concentrations should be determined by the end user.
理論分子量；28kDa
細(xì)胞定位；細(xì)胞核
性 狀；Liquid
濃 度；1mg/ml
免 疫 原；KLH
conjugated synthetic peptide derived from human MMS21/NSE2: 21-120/247
亞 型；IgG
純化方法；affinity
purified by Protein A
緩 沖 液；0.01M
TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件；Shipped at
4℃. Store at -20 °C for one
year. Avoid repeated freeze/thaw cycles.
注意事項(xiàng)；This
product as supplied is intended for research use only, not for use in human,
therapeutic or diagnostic applications.
產(chǎn)品介紹:
Breaks in double stranded DNA often arise during
DNA replication or as a result of exposure to DNA-damaging agents. Quick and
accurate repair of these breaks is crucial for cell survival and genomic
stability. Structural maintenance of chromosomes (SMC) family members form
heterodimeric complexes that modulate sister chromatid cohesion and
chromosome condensation during mitosis. SMC5 and SMC6 play a crucial role in
DNA repair as they form a complex with six conserved nonSMC subunits,
including a ubiquitin E3 ligase NSE1 and a SUMO ligase NSE2. Specifically,
this complex is crucial for sister chromatid homologous recombination DNA
repair and also for prevention of chromosomal rearrangements. The NSE1
protein contains a RING-like motif that promotes DNA repair functions of the
SMC5/SMC6 complex and full deletion of NSE1 is lethal to cells. NSE2
stimulates sumoylation of SMC6 and the DNA repair protein TRAX. Depletion of
the NSE2 protein by RNA interference leaves the cell vulnerable to DNA
damage-induced apoptosis. Function: E3 SUMO-protein ligase component of the SMC5-SMC6
complex, a complex involved in DNA double-strand breaks by homologous
recombination. The complex may promote sister chromatid homologous
recombination by recruiting the SMC1-SMC3 cohesin complex to double-strand
breaks. Acts as a E3 ligase mediating SUMO attachment to various proteins
such as SMC6L1 and TRAX, and maybe the cohesin components RAD21 and STAG2.
SUMO protein-ligase activity is required for the prevention of DNA
damage-induced apoptosis by facilitating DNA repair. |
多克隆抗體制備：
我公司合成抗原，保證陽性血清和抗體ELISA效價(jià)達(dá)到1：32000，由蛋白抗原制備的多抗，保證WB檢測結(jié)果是陽性。技術(shù)服務(wù)實(shí)行分步報(bào)價(jià)，按節(jié)點(diǎn)收費(fèi)，為客戶節(jié)約成本。
鼠單克隆抗體制備:
客戶可根據(jù)項(xiàng)目實(shí)際需求情況靈活選擇進(jìn)行，我公司將為您的項(xiàng)目提供專業(yè)的建議。在制備過程中，與客戶互動驗(yàn)證，確保最終制備的抗體ELISA陽性血清檢測達(dá)到合同要求的同時(shí)，也能滿足客戶抗體最終應(yīng)用驗(yàn)證需求。技術(shù)服務(wù)實(shí)行分步報(bào)價(jià)，按節(jié)點(diǎn)收費(fèi)，為客戶節(jié)約成本。
重組抗體表達(dá)服務(wù):
重組抗體技術(shù)使制備人源化抗體和人源抗體成為可能，而這是其他常規(guī)的多克隆或單克隆抗體制備方法無法做到的。我公司已搭建好的抗體測序、重組抗體表達(dá)等先進(jìn)平臺，能為客戶提供各種類型的重組抗體表達(dá)服務(wù)，包含鼠源單克隆抗體構(gòu)建及表達(dá)、更換恒定區(qū)亞型的嵌合抗體表達(dá)，抗體人源化改造及表達(dá)等服務(wù)。
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我公司也為客戶提供單項(xiàng)免疫學(xué)和檢測服務(wù)，如動物免疫、動物飼養(yǎng)、抗體修飾服務(wù)（如FITC，HRP等的標(biāo)記）、以及ELISA，WB，IHC，DB等檢測服務(wù)。
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