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簡(jiǎn)要描述：p400蛋白抗體免 疫 原；KLH conjugated synthetic peptide derived from human p400: 1051-1250/3159
產(chǎn)品型號(hào)：GOY-01K4160廠(chǎng)商性質(zhì)：科研更新時(shí)間：2023-10-24 00:00:00訪(fǎng) 問(wèn) 量：169產(chǎn)品分類(lèi)
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p400蛋白抗體
產(chǎn)品名稱(chēng) | 英文名稱(chēng) | 貨號(hào) |
p400蛋白抗體 | p400 | GOY-01K4160 |
商品屬性：
英文名稱(chēng): p400
中文名:p400蛋白抗體
別 名；CAG repeat
protein 32; CAGH32; DKFZP434I225; Domino homolog; E1A binding protein p400; EP
400; EP400; FLJ42018; FLJ45115; hDomino; KIAA1498; KIAA1818; p400 kDa SWI2/SNF2
related protein; P400 SWI2/SNF2-related protein; TNRC12; Trinucleotide repeat
containing 12; Trinucleotide repeat containing gene 12 protein; EP400_HUMAN.
研究領(lǐng)域；腫瘤 細(xì)胞生物 免疫學(xué) 轉(zhuǎn)錄調(diào)節(jié)因子 表觀(guān)遺傳學(xué)
抗體來(lái)源；Rabbit
克隆類(lèi)型；Polyclonal
交叉反應(yīng)；(predicted:
Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, )
產(chǎn)品應(yīng)用；ELISA=1:5000-10000
IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)）
not yet tested in
other applications.
optimal
dilutions/concentrations should be determined by the end user.
理論分子量；344kDa
細(xì)胞定位；細(xì)胞核
性 狀；Liquid
濃 度；1mg/ml
免 疫 原；KLH
conjugated synthetic peptide derived from human p400: 1051-1250/3159
亞 型；IgG
純化方法；affinity
purified by Protein A
緩 沖 液；0.01M
TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
注意事項(xiàng)；This
product as supplied is intended for research use only, not for use in human,
therapeutic or diagnostic applications.
產(chǎn)品介紹:
NuAR is a multi-protein histone acetyltransferase
complex that functions to acetylate the nucleosomal Histones H4 and H2A,
thereby activating transcription of select target genes. p400, also known as
EP400 (E1A binding protein p400) or mDomino, localizes to the nucleus and is
a component of the NuAR complex. Expressed in brain, liver, thymus, lung,
spleen, colon and kidney, p400 regulates the transcriptional activity of
proteins such as MZF-1 and contributes to the ATPase and helicase activities
of NuA4. p400 is a SWI2/ SNF2-related protein that can interact with the
adenovirus oncoprotein E1A, thus activating the proapoptotic activity of E1A.
The ability of p400 to regulate transcriptional and apoptotic activity
suggests that the NuAR complex may be a crucial component of cell proliferation,
transformation and, possibly, carcinogenesis. Five isoforms of p400 exist due
to alternative splicing events. Component of the NuA4 histone acetyltransferase
complex which is involved in transcriptional activation of select genes
principally by acetylation of nucleosomal histones H4 and H2A. This
modification may both alter nucleosome - DNA interactions and promote
interaction of the modified histones with other proteins which positively
regulate transcription. May be required for transcriptional activation of
E2F1 and MYC target genes during cellular proliferation. The NuA4 complex
ATPase and helicase activities seem to be, at least in part, contributed by
the association of RUVBL1 and RUVBL2 with EP400. May regulate ZNF42
transcription activity. |
多克隆抗體制備：
我公司合成抗原，保證陽(yáng)性血清和抗體ELISA效價(jià)達(dá)到1：32000，由蛋白抗原制備的多抗，保證WB檢測(cè)結(jié)果是陽(yáng)性。技術(shù)服務(wù)實(shí)行分步報(bào)價(jià)，按節(jié)點(diǎn)收費(fèi)，為客戶(hù)節(jié)約成本。
鼠單克隆抗體制備:
客戶(hù)可根據(jù)項(xiàng)目實(shí)際需求情況靈活選擇進(jìn)行，我公司將為您的項(xiàng)目提供專(zhuān)業(yè)的建議。在制備過(guò)程中，與客戶(hù)互動(dòng)驗(yàn)證，確保最終制備的抗體ELISA陽(yáng)性血清檢測(cè)達(dá)到合同要求的同時(shí)，也能滿(mǎn)足客戶(hù)抗體最終應(yīng)用驗(yàn)證需求。技術(shù)服務(wù)實(shí)行分步報(bào)價(jià)，按節(jié)點(diǎn)收費(fèi)，為客戶(hù)節(jié)約成本。
重組抗體表達(dá)服務(wù):
重組抗體技術(shù)使制備人源化抗體和人源抗體成為可能，而這是其他常規(guī)的多克隆或單克隆抗體制備方法無(wú)法做到的。我公司已搭建好的抗體測(cè)序、重組抗體表達(dá)等先進(jìn)平臺(tái)，能為客戶(hù)提供各種類(lèi)型的重組抗體表達(dá)服務(wù)，包含鼠源單克隆抗體構(gòu)建及表達(dá)、更換恒定區(qū)亞型的嵌合抗體表達(dá)，抗體人源化改造及表達(dá)等服務(wù)。
單項(xiàng)免疫學(xué)及檢測(cè)服務(wù):
我公司也為客戶(hù)提供單項(xiàng)免疫學(xué)和檢測(cè)服務(wù)，如動(dòng)物免疫、動(dòng)物飼養(yǎng)、抗體修飾服務(wù)（如FITC，HRP等的標(biāo)記）、以及ELISA，WB，IHC，DB等檢測(cè)服務(wù)。
抗體定制服務(wù):
已注冊(cè)商標(biāo)，主要用于抗體藥物發(fā)現(xiàn)和開(kāi)發(fā)，是我公司針對(duì)有特定應(yīng)用要求和各種模型測(cè)試的客戶(hù)量身定制的專(zhuān)業(yè)服務(wù)，主要面向工業(yè)客戶(hù)。
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