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簡要描述：RAS相關(guān)蛋白Rab5B抗體免 疫 原；KLH conjugated synthetic peptide derived from human Rab5b: 15-120/215
產(chǎn)品型號：GOY-01K2305廠商性質(zhì)：科研更新時間：2023-10-24 00:00:00訪 問 量：161產(chǎn)品分類
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RAS相關(guān)蛋白Rab5B抗體
產(chǎn)品名稱 | 英文名稱 | 貨號 |
RAS相關(guān)蛋白Rab5B抗體 | RAB5B | GOY-01K2305 |
商品屬性：
英文名稱: RAB5B
中文名:RAS相關(guān)蛋白Rab5B抗體
別 名；Rab 5b; Rab5 b;
RAB5B, member RAS oncogene family; Ras related protein Rab 5B; RAB5B_HUMAN.
研究領(lǐng)域；神經(jīng)生物學(xué) 信號轉(zhuǎn)導(dǎo)
抗體來源；Rabbit
克隆類型；Polyclonal
交叉反應(yīng)；(predicted:
Human, Mouse, Rat, Chicken, Pig, Cow, Horse, Rabbit, Sheep, )
產(chǎn)品應(yīng)用；WB=1:500-2000
ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)）
not yet tested in
other applications.
optimal
dilutions/concentrations should be determined by the end user.
理論分子量；24kDa
細(xì)胞定位；細(xì)胞漿 細(xì)胞膜
性 狀；Liquid
濃 度；1mg/ml
免 疫 原；KLH
conjugated synthetic peptide derived from human Rab5b: 15-120/215
亞 型；IgG
純化方法；affinity
purified by Protein A
緩 沖 液；0.01M
TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
注意事項；This
product as supplied is intended for research use only, not for use in human,
therapeutic or diagnostic applications.
產(chǎn)品介紹:
The Ras-related superfamily of guanine nucleotide
binding proteins, which includes the R-Ras, Rap, Ral/Rec and Rho/Rab
subfamilies, exhibit 30-60% homology with Ras p21. Accumulating data suggests
an important role for Rab proteins, either in endocytosis or in biosynthetic
protein transport. The transport of newly synthesized proteins from the
endoplasmic reticulum to various stacks of the Golgi complex and to secretory
vesicles involves at each stage the movement of carrier vesicles, a process
that appears to involve Rab protein function. The possibility that Rab
proteins might also direct the exocytosis from secretory vesicles to the
plasma membrane is supported by the observation that in yeast, the SEC4
protein, which is 40% homologous to Rab proteins, is associated with
secretory vesicles. At least eight members of the Rab subfamily have been
identified, each of which is found at a particular stage of a membrane
transport pathway. Rab5b is a member of the Rab family of small
(monomeric) G proteins. Like other small G proteins, Rab5b switches between
an inactive, GDP-form and an active, GTP-bound form. GDP/GTP exchange factors
(GEFs) catalyse the conversion from the GDP-bound form to the GTP-bound form,
while GTPase-activating proteins (GAPs) catalyse GTP hydrolysis to GDP. Rab5b
is involved in endocytosis and recycling of cell surface molecules. It
interacts with RIN2 and RIN3, which regulate its function, possibly by acting
as GEFs. Knockdown of Rab5b abolished group I metabotropic glutamate receptor
(mGluR)-mediated neuroprotection. Furthermore, Rab5b interacts with LRRK2,
the defective gene at the PARK8 locus that results in Parkinson's disease.
Roles for Rab5b in neurodegenerative disease, neuroprotection, and synaptic
plasticity have been suggested. |
多克隆抗體制備：
我公司合成抗原，保證陽性血清和抗體ELISA效價達到1：32000，由蛋白抗原制備的多抗，保證WB檢測結(jié)果是陽性。技術(shù)服務(wù)實行分步報價，按節(jié)點收費，為客戶節(jié)約成本。
鼠單克隆抗體制備:
客戶可根據(jù)項目實際需求情況靈活選擇進行，我公司將為您的項目提供專業(yè)的建議。在制備過程中，與客戶互動驗證，確保最終制備的抗體ELISA陽性血清檢測達到合同要求的同時，也能滿足客戶抗體最終應(yīng)用驗證需求。技術(shù)服務(wù)實行分步報價，按節(jié)點收費，為客戶節(jié)約成本。
重組抗體表達服務(wù):
重組抗體技術(shù)使制備人源化抗體和人源抗體成為可能，而這是其他常規(guī)的多克隆或單克隆抗體制備方法無法做到的。我公司已搭建好的抗體測序、重組抗體表達等先進平臺，能為客戶提供各種類型的重組抗體表達服務(wù)，包含鼠源單克隆抗體構(gòu)建及表達、更換恒定區(qū)亞型的嵌合抗體表達，抗體人源化改造及表達等服務(wù)。
單項免疫學(xué)及檢測服務(wù):
我公司也為客戶提供單項免疫學(xué)和檢測服務(wù)，如動物免疫、動物飼養(yǎng)、抗體修飾服務(wù)（如FITC，HRP等的標(biāo)記）、以及ELISA，WB，IHC，DB等檢測服務(wù)。
抗體定制服務(wù):
已注冊商標(biāo)，主要用于抗體藥物發(fā)現(xiàn)和開發(fā)，是我公司針對有特定應(yīng)用要求和各種模型測試的客戶量身定制的專業(yè)服務(wù)，主要面向工業(yè)客戶。
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