簡要描述:TANK抗體免 疫 原;KLH conjugated synthetic peptide derived from human TANK: 151-260/425
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TANK抗體
產(chǎn)品名稱 | 英文名稱 | 貨號 |
TANK抗體 | TANK | GOY-01K2046 |
商品屬性:
英文名稱: TANK
中文名:TANK抗體
別 名;I TRAF; ITRAF;
TRAF family member associated NF KAPPA B activator; TRAF family member
associated NFKB activator; TRAF interacting protein; TRAF interacting protein
TANK isoform a; I-TRAF; Tank; TANK_HUMAN; TRAF family member-associated
NF-kappa-B activator; TRAF-interacting protein; TRAF interacting protein TANK
isoform b; TRAF2.
研究領域;細胞生物 免疫學 信號轉導 生長因子和激素
抗體來源;Rabbit
克隆類型;Polyclonal
交叉反應;(predicted: Human, Mouse, Rat, )
產(chǎn)品應用;ELISA=1:5000-10000
IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 (石蠟切片需做抗原修復)
not yet tested in
other applications.
optimal dilutions/concentrations
should be determined by the end user.
理論分子量;48kDa
細胞定位;細胞核 細胞漿
性 狀;Liquid
濃 度;1mg/ml
免 疫 原;KLH
conjugated synthetic peptide derived from human TANK: 151-260/425
亞 型;IgG
純化方法;affinity
purified by Protein A
緩 沖 液;0.01M TBS(pH7.4)
with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
注意事項;This
product as supplied is intended for research use only, not for use in human,
therapeutic or diagnostic applications.
產(chǎn)品介紹:
TANK was initially identified as a novel
TRAF-interacting protein that regulated TRAF-mediated signal transduction.
Specifically, ligand binding by surface receptors in the tumor necrosis
factor (TNF) receptor and Toll/interleukin-1 (IL-1) receptor families lead to
the formation of a TRAF/TANK complex that mediates the activation of the
transcription factor NF-kappaB. TANK is found in the cytoplasm and can bind
to TRAF1, TRAF2, or TRAF3, thereby inhibiting TRAF function by sequestering
the TRAFs in a latent state in the cytoplasm. For example, this protein can
block TRAF2 binding to LMP1, the Epstein Barr virus transforming protein, and
inhibit LMP1-mediated NF kappa B activation. Acts as a regulator of TRAF function by
maintaining them in a latent state. Overexpression inhibits TRAF2-mediated
NF-kappa-B activation signaled by CD40, TNFR1 and TNFR2. Blocks TRAF2 binding
to LMP1 and inhibits LMP1-mediated NF-kappa-B activation. May be involved in
I-kappa-B-kinase (IKK) regulation; may function as an adapter for kinases
such as TBK1 or IKBKE that can modulate IKK activity. |
多克隆抗體制備:
我公司合成抗原,保證陽性血清和抗體ELISA效價達到1:32000,由蛋白抗原制備的多抗,保證WB檢測結果是陽性。技術服務實行分步報價,按節(jié)點收費,為客戶節(jié)約成本。
鼠單克隆抗體制備:
客戶可根據(jù)項目實際需求情況靈活選擇進行,我公司將為您的項目提供專業(yè)的建議。在制備過程中,與客戶互動驗證,確保最終制備的抗體ELISA陽性血清檢測達到合同要求的同時,也能滿足客戶抗體最終應用驗證需求。技術服務實行分步報價,按節(jié)點收費,為客戶節(jié)約成本。
重組抗體表達服務:
重組抗體技術使制備人源化抗體和人源抗體成為可能,而這是其他常規(guī)的多克隆或單克隆抗體制備方法無法做到的。我公司已搭建好的抗體測序、重組抗體表達等先進平臺,能為客戶提供各種類型的重組抗體表達服務,包含鼠源單克隆抗體構建及表達、更換恒定區(qū)亞型的嵌合抗體表達,抗體人源化改造及表達等服務。
單項免疫學及檢測服務:
我公司也為客戶提供單項免疫學和檢測服務,如動物免疫、動物飼養(yǎng)、抗體修飾服務(如FITC,HRP等的標記)、以及ELISA,WB,IHC,DB等檢測服務。
抗體定制服務:
已注冊商標,主要用于抗體藥物發(fā)現(xiàn)和開發(fā),是我公司針對有特定應用要求和各種模型測試的客戶量身定制的專業(yè)服務,主要面向工業(yè)客戶。
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