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簡(jiǎn)要描述：泛素蛋白連接酶E3α2抗體免 疫 原；KLH conjugated synthetic peptide derived from human UBR2: 801-900/1755
產(chǎn)品型號(hào)：GOY-01K1905廠商性質(zhì)：科研更新時(shí)間：2023-10-24 00:00:00訪 問 量：178產(chǎn)品分類
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泛素蛋白連接酶E3α2抗體
產(chǎn)品名稱 | 英文名稱 | 貨號(hào) |
泛素蛋白連接酶E3α2抗體 | UBR2 | GOY-01K1905 |
商品屬性：
英文名稱: UBR2
中文名:泛素蛋白連接酶E3α2抗體
別 名；E3 ubiquitin
protein ligase UBR2; N recognin 2; Ubiquitin ligase E3 alpha II; Ubiquitin
protein ligase E3 alpha 2; Ubiquitin protein ligase E3 component n recognin 2;
UBR 2; UBR2_HUMAN; N-recognin-2; Ubiquitin-protein ligase E3-alpha-2;
Ubiquitin-protein ligase E3-alpha-II.
研究領(lǐng)域；細(xì)胞生物 免疫學(xué) 發(fā)育生物學(xué)
抗體來源；Rabbit
克隆類型；Polyclonal
交叉反應(yīng)；(predicted:
Human, Mouse, Rat, Chicken, Dog, Pig, Cow, Horse, Sheep, )
產(chǎn)品應(yīng)用；WB=1:500-2000
ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:50-200 （石蠟切片需做抗原修復(fù)）
not yet tested in
other applications.
optimal
dilutions/concentrations should be determined by the end user.
理論分子量；44kDa
細(xì)胞定位；細(xì)胞核
性 狀；Liquid
濃 度；1mg/ml
免 疫 原；KLH
conjugated synthetic peptide derived from human UBR2: 801-900/1755
亞 型；IgG
純化方法；affinity purified
by Protein A
緩 沖 液；0.01M
TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
注意事項(xiàng)；This
product as supplied is intended for research use only, not for use in human,
therapeutic or diagnostic applications.
產(chǎn)品介紹:
Ubiquitination is an important mechanism through
which three classes of enzymes act in concert to target short-lived or
abnormal proteins for destruction. The three classes of enzymes involved in
ubiquitination are the ubiquitin-activating enzymes (E1s), the
ubiquitin-conjugating enzymes (E2s) and the ubiquitin-protein ligases (E3s).
Ubr2 (Ubiquitin-protein ligase E3-alpha-2), also known as N-recognin-2, is a
1755 amino acid protein that contains one UBR-type zinc finger and one
RING-type zinc finger. Participating in protein modification events within
the N-end rule pathway, Ubr2 functions as an E3 ubiquitin-protein ligase that
recognizes and binds proteins that contain destabilizing N-terminal residues,
thereby leading to their ubiquitination and subsequent degradation. Mice
lacking Ubr2 are infertile due to defects in male meiosis. E3 ubiquitin-protein ligase which is a component
of the N-end rule pathway. Recognizes and binds to proteins bearing specific
N-terminal residues that are destabilizing according to the N-end rule,
leading to their ubiquitination and subsequent degradation. Plays a critical
role in chromatin inactivation and chromosome-wide transcriptional silencing
during meiosis via ubiquitination of histone H2A. Binds leucine and is a
negative regulator of the leucine-mTOR signaling pathway, thereby controlling
cell growth. |
多克隆抗體制備：
我公司合成抗原，保證陽性血清和抗體ELISA效價(jià)達(dá)到1：32000，由蛋白抗原制備的多抗，保證WB檢測(cè)結(jié)果是陽性。技術(shù)服務(wù)實(shí)行分步報(bào)價(jià)，按節(jié)點(diǎn)收費(fèi)，為客戶節(jié)約成本。
鼠單克隆抗體制備:
客戶可根據(jù)項(xiàng)目實(shí)際需求情況靈活選擇進(jìn)行，我公司將為您的項(xiàng)目提供專業(yè)的建議。在制備過程中，與客戶互動(dòng)驗(yàn)證，確保最終制備的抗體ELISA陽性血清檢測(cè)達(dá)到合同要求的同時(shí)，也能滿足客戶抗體最終應(yīng)用驗(yàn)證需求。技術(shù)服務(wù)實(shí)行分步報(bào)價(jià)，按節(jié)點(diǎn)收費(fèi)，為客戶節(jié)約成本。
重組抗體表達(dá)服務(wù):
重組抗體技術(shù)使制備人源化抗體和人源抗體成為可能，而這是其他常規(guī)的多克隆或單克隆抗體制備方法無法做到的。我公司已搭建好的抗體測(cè)序、重組抗體表達(dá)等先進(jìn)平臺(tái)，能為客戶提供各種類型的重組抗體表達(dá)服務(wù)，包含鼠源單克隆抗體構(gòu)建及表達(dá)、更換恒定區(qū)亞型的嵌合抗體表達(dá)，抗體人源化改造及表達(dá)等服務(wù)。
單項(xiàng)免疫學(xué)及檢測(cè)服務(wù):
我公司也為客戶提供單項(xiàng)免疫學(xué)和檢測(cè)服務(wù)，如動(dòng)物免疫、動(dòng)物飼養(yǎng)、抗體修飾服務(wù)（如FITC，HRP等的標(biāo)記）、以及ELISA，WB，IHC，DB等檢測(cè)服務(wù)。
抗體定制服務(wù):
已注冊(cè)商標(biāo)，主要用于抗體藥物發(fā)現(xiàn)和開發(fā)，是我公司針對(duì)有特定應(yīng)用要求和各種模型測(cè)試的客戶量身定制的專業(yè)服務(wù)，主要面向工業(yè)客戶。
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