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凋亡相關蛋白激酶3抗體
產品名稱 | 英文名稱 | 貨號 |
凋亡相關蛋白激酶3抗體 | ZIP Kinase | GOY-01K2050 |
商品屬性：
英文名稱: ZIP Kinase
中文名:凋亡相關蛋白激酶3抗體
別 名；DAPK3; Death
associated protein kinase 3; DAP kinase 3; DAP like kinase; Dapk 3; Dapk3;
Death associated kinase 3; Death associated protein kinase 3; Dlk; EC 2.7.11.1;
FLJ36473; ZIP; ZIP kinase; ZIPK; DAPK3_HUMAN.
研究領域；染色質和核信號 信號轉導 轉錄調節(jié)因子
抗體來源；Rabbit
克隆類型；Polyclonal
交叉反應；(predicted:
Human, Mouse, Rat, Chicken, Dog, Cow, Horse, Rabbit, )
產品應用；WB=1:500-2000
ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復）
not yet tested in
other applications.
optimal dilutions/concentrations
should be determined by the end user.
理論分子量；52kDa
細胞定位；細胞核
性 狀；Liquid
濃 度；1mg/ml
免 疫 原；KLH
conjugated synthetic peptide derived from human DAPK3: 30-130/454
亞 型；IgG
純化方法；affinity
purified by Protein A
緩 沖 液；0.01M
TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
注意事項；This
product as supplied is intended for research use only, not for use in human,
therapeutic or diagnostic applications.
產品介紹:
Apoptosis is mediated by death domain containing
adapter molecules and a caspase family of proteases. Certainserine/threonine
protein kinases, such as ASK1 and RIP, are mediators of apoptosis. A novel
serine/threonine kinase that mediates apoptosis was recently identified and
designated ZIP kinase. ZIP kinase contains an N terminal kinase domain and a
C terminal leucine zipper structure and binds to ATF4 that is a member of
ATF/CREBfamily. ZIP kinase has high sequence homology to DAP kinase (death
associated protein kinase), which is a mediator of apoptosis induced by gamma
interferon. Overexpression of ZIP kinase induces apoptosis. ZIP and DAP
kinases represent a novel kinase family, which mediates apoptosis through
their catalytic activities. The messenger RNA was ubiquitously expressed in
various tissues. Serine/threonine kinase which is involved in the
regulation of apoptosis, autophagy, transcription, translation, actin
cytoskeleton reorganization, cell motility, smooth muscle contraction, and
mitosis, particularly cytokinesis. Regulates both type I apoptotic and type
II autophagic cell deaths signal, depending on the cellular setting. The
former is caspase-dependent, while the latter is caspase-independent and is
characterized by the accumulation of autophagic vesicles. Regulates myosin
phosphorylation in both smooth muscle and non-muscle cells. In smooth muscle,
regulates myosin either directly by phosphorylating MYL12B and MYL9 or
through inhibition of smooth muscle myosin phosphatase (SMPP1M) via
phosphorylation of PPP1R12A, and the inhibition of SMPP1M functions to enhance
muscle responsiveness to Ca(2+) and promote a contractile state. Enhances
transcription from AR-responsive promoters in a hormone- and kinase-dependent
manner. Phosphorylates STAT3 and enhances its transcriptional activity.
Positively regulates the canonical Wnt/beta-catenin signaling through
interaction with NLK and TCF7L2. Can disrupt the NLK-TCF7L2 complex thereby
influencing the phosphorylation of TCF7L2 by NLK. Phosphorylates histone H3
on 'Thr-11' at centromeres during mitosis. Involved in the formation of
promyelocytic leukemia protein nuclear body (PML-NB), one of many subnuclear
domains in the eukaryotic cell nucleus, and which is involved in oncogenesis
and viral infection. Phosphorylates RPL13A on 'Ser-77' upon interferon-gamma
activation which is causing RPL13A release from the ribosome, its association
with the GAIT complex and its subsequent involvement in transcript-selective
translation inhibition. Isoform 2 can phosphorylate myosin, PPP1R12A and
MYL12B |
多克隆抗體制備：
我公司合成抗原，保證陽性血清和抗體ELISA效價達到1：32000，由蛋白抗原制備的多抗，保證WB檢測結果是陽性。技術服務實行分步報價，按節(jié)點收費，為客戶節(jié)約成本。
鼠單克隆抗體制備:
客戶可根據項目實際需求情況靈活選擇進行，我公司將為您的項目提供專業(yè)的建議。在制備過程中，與客戶互動驗證，確保最終制備的抗體ELISA陽性血清檢測達到合同要求的同時，也能滿足客戶抗體最終應用驗證需求。技術服務實行分步報價，按節(jié)點收費，為客戶節(jié)約成本。
重組抗體表達服務:
重組抗體技術使制備人源化抗體和人源抗體成為可能，而這是其他常規(guī)的多克隆或單克隆抗體制備方法無法做到的。我公司已搭建好的抗體測序、重組抗體表達等先進平臺，能為客戶提供各種類型的重組抗體表達服務，包含鼠源單克隆抗體構建及表達、更換恒定區(qū)亞型的嵌合抗體表達，抗體人源化改造及表達等服務。
單項免疫學及檢測服務:
我公司也為客戶提供單項免疫學和檢測服務，如動物免疫、動物飼養(yǎng)、抗體修飾服務（如FITC，HRP等的標記）、以及ELISA，WB，IHC，DB等檢測服務。
抗體定制服務:
已注冊商標，主要用于抗體藥物發(fā)現和開發(fā)，是我公司針對有特定應用要求和各種模型測試的客戶量身定制的專業(yè)服務，主要面向工業(yè)客戶。
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