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簡要描述：激活素受體1B抗體免 疫 原；KLH conjugated synthetic peptide derived from human Activin A Receptor Type IB: 301-400/505
產(chǎn)品型號：GOY-01K1894廠商性質(zhì)：科研更新時間：2023-10-24 00:00:00訪 問 量：574產(chǎn)品分類
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激活素受體1B抗體
產(chǎn)品名稱 | 英文名稱 | 貨號 |
激活素受體1B抗體 | ACVR1B | GOY-01K1894 |
商品屬性：
英文名稱: ACVR1B
中文名:激活素受體1B抗體
別 名；Activin A receptor
type 1B; Activin A receptor type II like kinase 4; Activin A type 1B receptor;
Activin A type IB receptor; Activin receptor like kinase 4; Activin receptor
type 1B; ACTR IB; ACTRIB; ACVR 1B; ACVRLK 4; ACVRLK4; ALK 4; ALK4;
Serine(threonine) protein kinase receptor R2; SKR 2; SKR2.
研究領(lǐng)域；腫瘤 免疫學(xué) 信號轉(zhuǎn)導(dǎo) 轉(zhuǎn)錄調(diào)節(jié)因子 激酶和磷酸酶
抗體來源；Rabbit
克隆類型；Polyclonal
交叉反應(yīng)；(predicted:
Human, Mouse, Rat, Dog, Pig, Cow, Horse, )
產(chǎn)品應(yīng)用；ELISA=1:5000-10000
IHC-P=1:100-500 IHC-F=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)）
not yet tested in
other applications.
optimal
dilutions/concentrations should be determined by the end user.
理論分子量；53kDa
細胞定位；細胞膜
性 狀；Liquid
濃 度；1mg/ml
免 疫 原；KLH
conjugated synthetic peptide derived from human Activin A Receptor Type IB:
301-400/505
亞 型；IgG
純化方法；affinity
purified by Protein A
緩 沖 液；0.01M
TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
注意事項；This
product as supplied is intended for research use only, not for use in human,
therapeutic or diagnostic applications.
產(chǎn)品介紹:
Activins are dimeric growth and differentiation
factors which belong to the transforming growth factor beta (TGF beta)
superfamily of structurally related signaling proteins. Activins signal
through a heteromeric complex of receptor serine kinases which include at
least two type I (I and IB) and two type II (II and IIB) receptors. These
receptors are all transmembrane proteins, composed of a ligand binding
extracellular domain with a cysteine rich region, a transmembrane domain, and
a cytoplasmic domain with predicted serine/threonine specificity. Type I
receptors are essential for signaling, and type II receptors are required for
binding ligands and for expression of type I receptors. Transmembrane serine/threonine kinase activin
type-1 receptor forming an activin receptor complex with activin receptor
type-2 (ACVR2A or ACVR2B). Transduces the activin signal from the cell
surface to the cytoplasm and is thus regulating a many physiological and
pathological processes including neuronal differentiation and neuronal
survival, hair follicle development and cycling, FSH production by the
pituitary gland, wound healing, extracellular matrix production,
immunosuppression and carcinogenesis. Activin is also thought to have a
paracrine or autocrine role in follicular development in the ovary. Within
the receptor complex, type-2 receptors (ACVR2A and/or ACVR2B) act as a
primary activin receptors whereas the type-1 receptors like ACVR1B act as
downstream transducers of activin signals. Activin binds to type-2 receptor
at the plasma membrane and activates its serine-threonine kinase. The
activated receptor type-2 then phosphorylates and activates the type-1
receptor such as ACVR1B. Once activated, the type-1 receptor binds and
phosphorylates the SMAD proteins SMAD2 and SMAD3, on serine residues of the
C-terminal tail. Soon after their association with the activin receptor and
subsequent phosphorylation, SMAD2 and SMAD3 are released into the cytoplasm
where they interact with the common partner SMAD4. This SMAD complex
translocates into the nucleus where it mediates activin-induced
transcription. Inhibitory SMAD7, which is recruited to ACVR1B through FKBP1A,
can prevent the association of SMAD2 and SMAD3 with the activin receptor
complex, thereby blocking the activin signal. Activin signal transduction is
also antagonized by the binding to the receptor of inhibin-B via the IGSF1
inhibin coreceptor. ACVR1B also phosphorylates TDP2. |
多克隆抗體制備：
我公司合成抗原，保證陽性血清和抗體ELISA效價達到1：32000，由蛋白抗原制備的多抗，保證WB檢測結(jié)果是陽性。技術(shù)服務(wù)實行分步報價，按節(jié)點收費，為客戶節(jié)約成本。
鼠單克隆抗體制備:
客戶可根據(jù)項目實際需求情況靈活選擇進行，我公司將為您的項目提供專業(yè)的建議。在制備過程中，與客戶互動驗證，確保最終制備的抗體ELISA陽性血清檢測達到合同要求的同時，也能滿足客戶抗體最終應(yīng)用驗證需求。技術(shù)服務(wù)實行分步報價，按節(jié)點收費，為客戶節(jié)約成本。
重組抗體表達服務(wù):
重組抗體技術(shù)使制備人源化抗體和人源抗體成為可能，而這是其他常規(guī)的多克隆或單克隆抗體制備方法無法做到的。我公司已搭建好的抗體測序、重組抗體表達等先進平臺，能為客戶提供各種類型的重組抗體表達服務(wù)，包含鼠源單克隆抗體構(gòu)建及表達、更換恒定區(qū)亞型的嵌合抗體表達，抗體人源化改造及表達等服務(wù)。
單項免疫學(xué)及檢測服務(wù):
我公司也為客戶提供單項免疫學(xué)和檢測服務(wù)，如動物免疫、動物飼養(yǎng)、抗體修飾服務(wù)（如FITC，HRP等的標記）、以及ELISA，WB，IHC，DB等檢測服務(wù)。
抗體定制服務(wù):
已注冊商標，主要用于抗體藥物發(fā)現(xiàn)和開發(fā)，是我公司針對有特定應(yīng)用要求和各種模型測試的客戶量身定制的專業(yè)服務(wù)，主要面向工業(yè)客戶。
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