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簡(jiǎn)要描述：巨噬細(xì)胞調(diào)控相關(guān)蛋白LRRFIP1抗體免 疫 原；KLH conjugated synthetic peptide derived from human LRRFIP1: 121-220/808
產(chǎn)品型號(hào)：GOY-01K1170廠商性質(zhì)：科研更新時(shí)間：2023-10-24 00:00:00訪(fǎng) 問(wèn) 量：151產(chǎn)品分類(lèi)
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巨噬細(xì)胞調(diào)控相關(guān)蛋白LRRFIP1抗體
產(chǎn)品名稱(chēng) | 英文名稱(chēng) | 貨號(hào) |
巨噬細(xì)胞調(diào)控相關(guān)蛋白LRRFIP1抗體 | GCF2/LRRFIP1 | GOY-01K1170 |
商品屬性：
英文名稱(chēng): GCF2/LRRFIP1
中文名:巨噬細(xì)胞調(diào)控相關(guān)蛋白LRRFIP1抗體
別 名；FLAP 1; FLAP1;
FLIIAP 1; FLIIAP1; GC binding factor 2; GC-binding factor 2; GCF 2; GCF2; HUFI
1; HUFI1; Leucine rich repeat (in FLII) interacting protein 1; Leucine rich
repeat flightless interacting protein 1; Leucine-rich repeat
flightless-interacting protein 1; LRR FLII interacting protein 1; LRR
FLII-interacting protein 1; LRRF1_HUMAN; LRRFIP 1; Lrrfip1; MGC10947;
MGC119738; MGC119739; NEDD8 conjugating enzyme; TAR RNA interacting protein;
TAR RNA-interacting protein; Transcription factor 9 like; TRIP.
研究領(lǐng)域；細(xì)胞生物 信號(hào)轉(zhuǎn)導(dǎo) 轉(zhuǎn)錄調(diào)節(jié)因子 結(jié)合蛋白 細(xì)胞骨架 表觀遺傳學(xué)
抗體來(lái)源；Rabbit
克隆類(lèi)型；Polyclonal
交叉反應(yīng)；(predicted:
Human, Mouse, Rat, Dog, Pig, Cow, Horse, Sheep, )
產(chǎn)品應(yīng)用；ELISA=1:5000-10000
not yet tested in
other applications.
optimal
dilutions/concentrations should be determined by the end user.
理論分子量；89kDa
細(xì)胞定位；細(xì)胞核 細(xì)胞漿
性 狀；Liquid
濃 度；1mg/ml
免 疫 原；KLH conjugated
synthetic peptide derived from human LRRFIP1: 121-220/808
亞 型；IgG
純化方法；affinity
purified by Protein A
緩 沖 液；0.01M
TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
注意事項(xiàng)；This
product as supplied is intended for research use only, not for use in human,
therapeutic or diagnostic applications.
產(chǎn)品介紹:
LRRFIP1 is an 738 amino acid human protein whose
rodent counterpart is known as Lrrfip1 (also designated FLAP in mouse).
LRRFIP1 is also believed to control smooth muscle cell proliferation following
arterial injury through PDGF-A repression. The N-terminus of LRRFIP1 shows
high homology to the coiled-coil domain of FLAP, a protein which binds the
leucine-rich repeat (LRR) of Flightless I, and the interaction of LRRFIP1
with the LRR of Flightless I has been confirmed. LRRFIP1 does not bind
single-stranded DNA or RNA significantly and binds double-stranded DNA
weakly. In contrast, LRRFIP1 binds double-stranded RNA with high affinity,
and two molecules of LRRFIP1 bind the TaR stem. The RNA binding domain has
been identified and encompasses a lysine-rich motif. Flightless I has a
C-terminal TaR-like domain which binds Actin and therefore the association of
LRRFIP1 with the LRR of Flightless I may provide a link between the Actin
cytoskeleton and RNA in mammalian cells. Transcriptional repressor which preferentially
binds to the GC-rich consensus sequence (5'-AGCCCCCGGCG-3') and may regulate
expression of TNF, EGFR and PDGFA. May control smooth muscle cells
proliferation following artery injury through PDGFA repression. May also bind
double-stranded RNA. |
多克隆抗體制備：
我公司合成抗原，保證陽(yáng)性血清和抗體ELISA效價(jià)達(dá)到1：32000，由蛋白抗原制備的多抗，保證WB檢測(cè)結(jié)果是陽(yáng)性。技術(shù)服務(wù)實(shí)行分步報(bào)價(jià)，按節(jié)點(diǎn)收費(fèi)，為客戶(hù)節(jié)約成本。
鼠單克隆抗體制備:
客戶(hù)可根據(jù)項(xiàng)目實(shí)際需求情況靈活選擇進(jìn)行，我公司將為您的項(xiàng)目提供專(zhuān)業(yè)的建議。在制備過(guò)程中，與客戶(hù)互動(dòng)驗(yàn)證，確保最終制備的抗體ELISA陽(yáng)性血清檢測(cè)達(dá)到合同要求的同時(shí)，也能滿(mǎn)足客戶(hù)抗體最終應(yīng)用驗(yàn)證需求。技術(shù)服務(wù)實(shí)行分步報(bào)價(jià)，按節(jié)點(diǎn)收費(fèi)，為客戶(hù)節(jié)約成本。
重組抗體表達(dá)服務(wù):
重組抗體技術(shù)使制備人源化抗體和人源抗體成為可能，而這是其他常規(guī)的多克隆或單克隆抗體制備方法無(wú)法做到的。我公司已搭建好的抗體測(cè)序、重組抗體表達(dá)等先進(jìn)平臺(tái)，能為客戶(hù)提供各種類(lèi)型的重組抗體表達(dá)服務(wù)，包含鼠源單克隆抗體構(gòu)建及表達(dá)、更換恒定區(qū)亞型的嵌合抗體表達(dá)，抗體人源化改造及表達(dá)等服務(wù)。
單項(xiàng)免疫學(xué)及檢測(cè)服務(wù):
我公司也為客戶(hù)提供單項(xiàng)免疫學(xué)和檢測(cè)服務(wù)，如動(dòng)物免疫、動(dòng)物飼養(yǎng)、抗體修飾服務(wù)（如FITC，HRP等的標(biāo)記）、以及ELISA，WB，IHC，DB等檢測(cè)服務(wù)。
抗體定制服務(wù):
已注冊(cè)商標(biāo)，主要用于抗體藥物發(fā)現(xiàn)和開(kāi)發(fā)，是我公司針對(duì)有特定應(yīng)用要求和各種模型測(cè)試的客戶(hù)量身定制的專(zhuān)業(yè)服務(wù)，主要面向工業(yè)客戶(hù)。
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