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簡(jiǎn)要描述：人類免疫缺陷病毒2型/2型艾滋病病毒gp41+gp160抗體免 疫 原；KLH conjugated synthetic peptide derived from HIV2 gp120 + gp160: 311-380/858
產(chǎn)品型號(hào)：GOY-01K1286廠商性質(zhì)：科研更新時(shí)間：2023-10-24 00:00:00訪 問(wèn) 量：140產(chǎn)品分類
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人類免疫缺陷病毒2型/2型艾滋病病毒gp41+gp160抗體
產(chǎn)品名稱 | 英文名稱 | 貨號(hào) |
人類免疫缺陷病毒2型/2型艾滋病病毒gp41+gp160抗體 | HIV2 gp120 + gp160 | GOY-01K1286 |
商品屬性：
英文名稱: HIV2 gp120 + gp160
中文名:人類免疫缺陷病毒2型/2型艾滋病病毒gp41+gp160抗體
別 名；Gp120; Gp160;
HIV-2 gp120; HIV2 gp160; HIV2gp120; HIV2gp160; HIV 2; Human immunodeficiency
virus 2; Human Immunodeficiency Virus Type 2; ENV_HV2RO.
研究領(lǐng)域；細(xì)菌及病毒
抗體來(lái)源；Rabbit
克隆類型；Polyclonal
產(chǎn)品應(yīng)用；WB=1:500-2000
ELISA=1:5000-10000 IHC-P=1:100-500 IHC-F=1:100-500 ICC=1:100-500 IF=1:100-500 （石蠟切片需做抗原修復(fù)）
not yet tested in
other applications.
optimal
dilutions/concentrations should be determined by the end user.
性 狀；Liquid
濃 度；1mg/ml
免 疫 原；KLH
conjugated synthetic peptide derived from HIV2 gp120 + gp160: 311-380/858
亞 型；IgG
純化方法；affinity
purified by Protein A
緩 沖 液；0.01M
TBS(pH7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.
保存條件；Shipped at
4℃. Store at -20 °C for one
year. Avoid repeated freeze/thaw cycles.
注意事項(xiàng)；This
product as supplied is intended for research use only, not for use in human,
therapeutic or diagnostic applications.
產(chǎn)品介紹:
Human immunodeficiency virus type 2 (HIV2),
orginally isolated from patients in West Africa, is the dominant form of HIV
in West Africa capable of causing the acquired immunodeficiency syndrome
(AIDS). HIV2 is closely related to simian immunodeficiency viruses (SIV).
HIV1 and HIV2 share similarity in their genomes, transmission, clinical
features, immunological effects, and in their action of binding to the same
CD4 cellular receptor, but there are significant differences in the amino
acid and nucleotide sequences of HIV1 and HIV2, especially within their
envelope genes and proteins. Additionally, HIV2 may have a longer incubation
period and may be less pathogenic than HIV1. HIV2 gp36 is a transmembrane
protein located in the envelope of the virus specific to HIV2 that binds to
the putative cellular receptor proteins P45 and P62. Function: The surface protein gp120 (SU) attaches the virus
to the host lymphoid cell by binding to the primary receptor CD4. This
interaction induces a structural rearrangement creating a high affinity
binding site for a chemokine coreceptor like CXCR4 and/or CCR5. This peculiar
2 stage receptor-interaction strategy allows gp120 to maintain the highly
conserved coreceptor-binding site in a cryptic conformation, protected from
neutralizing antibodies. Since CD4 also displays a binding site for the
disulfide-isomerase P4HB/PDI, a P4HB/PDI-CD4-CXCR4-gp120 complex may form. In
that complex, P4HB/PDI could reach and reduce gp120 disulfide bonds, causing
major conformational changes in gp120. TXN, another PDI family member could
also be involved in disulfide rearrangements in Env during fusion. These
changes are transmitted to the transmembrane protein gp41 and are thought to
activate its fusogenic potential by unmasking its fusion peptide. |
多克隆抗體制備：
我公司合成抗原，保證陽(yáng)性血清和抗體ELISA效價(jià)達(dá)到1：32000，由蛋白抗原制備的多抗，保證WB檢測(cè)結(jié)果是陽(yáng)性。技術(shù)服務(wù)實(shí)行分步報(bào)價(jià)，按節(jié)點(diǎn)收費(fèi)，為客戶節(jié)約成本。
鼠單克隆抗體制備:
客戶可根據(jù)項(xiàng)目實(shí)際需求情況靈活選擇進(jìn)行，我公司將為您的項(xiàng)目提供專業(yè)的建議。在制備過(guò)程中，與客戶互動(dòng)驗(yàn)證，確保最終制備的抗體ELISA陽(yáng)性血清檢測(cè)達(dá)到合同要求的同時(shí)，也能滿足客戶抗體最終應(yīng)用驗(yàn)證需求。技術(shù)服務(wù)實(shí)行分步報(bào)價(jià)，按節(jié)點(diǎn)收費(fèi)，為客戶節(jié)約成本。
重組抗體表達(dá)服務(wù):
重組抗體技術(shù)使制備人源化抗體和人源抗體成為可能，而這是其他常規(guī)的多克隆或單克隆抗體制備方法無(wú)法做到的。我公司已搭建好的抗體測(cè)序、重組抗體表達(dá)等先進(jìn)平臺(tái)，能為客戶提供各種類型的重組抗體表達(dá)服務(wù)，包含鼠源單克隆抗體構(gòu)建及表達(dá)、更換恒定區(qū)亞型的嵌合抗體表達(dá)，抗體人源化改造及表達(dá)等服務(wù)。
單項(xiàng)免疫學(xué)及檢測(cè)服務(wù):
我公司也為客戶提供單項(xiàng)免疫學(xué)和檢測(cè)服務(wù)，如動(dòng)物免疫、動(dòng)物飼養(yǎng)、抗體修飾服務(wù)（如FITC，HRP等的標(biāo)記）、以及ELISA，WB，IHC，DB等檢測(cè)服務(wù)。
抗體定制服務(wù):
已注冊(cè)商標(biāo)，主要用于抗體藥物發(fā)現(xiàn)和開(kāi)發(fā)，是我公司針對(duì)有特定應(yīng)用要求和各種模型測(cè)試的客戶量身定制的專業(yè)服務(wù)，主要面向工業(yè)客戶。
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