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Related ArticlesHEPHL1蛋白抗體注意事項(xiàng);This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications.
丙型肝炎病毒E1抗體注意事項(xiàng);This product as supplied is intended for research use only, not for use in human, therapeutic or diagnostic applications. Function: E1 and E2 glycoproteins form a heterodimer that is involved in virus attachment to the host cell, virion internalization through clathrin-dependent endocytosis and fusion with host membrane. E1/E2 heterodimer binds to human LDLR, CD81 and SCARB1/SR-BI receptors, but this binding is not sufficient for infection, some additional liver specific cofactors may be needed. The fusion function may possibly be carried by E1. E2 inhibits human EIF2AK2/PKR activation, preventing the establishment of an antiviral state. E2 is a viral ligand for CD209/DC-SIGN and CLEC4M/DC-SIGNR, which are respectively found on dendritic cells (DCs), and on liver sinusoidal endothelial cells and macrophage-like cells of lymph node sinuses. These interactions allow capture of circulating HCV particles by these cells and subsequent transmission to permissive cells. DCs act as sentinels in various tissues where they entrap pathogens and convey them to local lymphoid tissue or lymph node for establishment of immunity. Capture of circulating HCV particles by these SIGN+ cells may facilitate virus infection of proximal hepatocytes and lymphocyte subpopulations and may be essential for the establishment of persistent infection.
胞漿鈣獨(dú)立磷脂酶A2抗體免 疫 原;KLH conjugated synthetic peptide derived from human CaIPLA2: 331-430/806
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